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Compound 974: A novel ALDH1A1 inhibitor. (A) Chemical structure of compound 974. (B) EC50 curve for 974 binding with purified ALDH1A1. (C) OVCAR3 (D) OVCAR5 were treated with increasing doses of 974 (0.5–100 µM) for 48 h, and an MTT assay was performed to measure viability. IC50 values were calculated using GraphPad Prism.
