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. 2022 Jul 12;14(7):1455. doi: 10.3390/pharmaceutics14071455

Figure 4.

Figure 4

AddaS03-like emulsions maintained high colloidal stability at various temperatures with the addition of TLR4 and/or lipidated TLR7/8 agonists. An AddaS03-like emulsion was used to incorporate INI-4001 (TLR7/8 agonist) and/or INI-2002 (TLR4 agonist). Agonists were incorporated at low (0.175 mM) or high (1.75 mM) target concentrations, singly or coencapsulated. Dynamic light scattering was used to measure (A) hydrodynamic diameter (Z.Avg, nm), (B) polydispersity (PDI), and (C) zeta potential (mV) after storage at 4, 25, or 40 °C. Physical properties are given as mean ± SEM for replicate emulsions (n = 4).