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. 2022 Jul 12;14(7):1455. doi: 10.3390/pharmaceutics14071455

Figure 6.

Figure 6

AddaS03-like emulsions, with or without toll-like receptor (TLR) agonists, result in neutralization of SARS-CoV-2 variants. A surrogate virus neutralization test (sVNT) was used to test the neutralization potential of serum taken fourteen days after the booster immunization. The percent reduction in the binding of recombinant ACE2 to the indicated SARS-CoV-2 protein is given for (A) RBD (A/Wuhan), (B) spike (A/Wuhan), (C) spike (D614G mutation), and spike from the variants of concern: (D) Alpha (B.1.1.7), (E) Beta (B.1.351), and (F) Gamma (P.1). Results are presented as box-and whisker plots representing the median and quartiles (box) and range (whiskers) overlaid with data from individual animals. A one-way ANOVA with a post hoc Tukey’s test for multiple comparisons demonstrated significant differences between group means (* p < 0.05 and **** p < 0.0001) when compared to unadjuvanted RBD (n = 6–8).