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. 2022 Jul 12;14(7):1455. doi: 10.3390/pharmaceutics14071455

Figure 7.

Figure 7

Addition of TLR4 or TLR7/8 agonists to AddaS03-like emulsions significantly skewed away from Th2-type cytokine profiles in the draining lymph node (DLN). Fourteen days post-secondary immunization, lymphocytes were isolated from the DLN, grown ex vivo, and stimulated with SARS-CoV-2 RBD for 72 h. RBD-specific (A) IFNγ, (B) IL-17A, and (C) IL-5 were measured in the cell supernatant for each group. A one-way ANOVA with a post hoc Tukey’s test for multiple comparisons demonstrated significant differences in group means when compared to the AddaS03-like (** p < 0.01, **** p < 0.0001) or MF59-like (# p < 0.05, ### p < 0.001, and #### p < 0.0001) emulsions alone.