Table 1.
Age, sex, main clinical characteristics and rs2431697 genotype of the ACS cohort vs. healthy donors.
| Healthy Donors (n = 300) | ACS Patients (n = 359) | p-Value | |
|---|---|---|---|
| Age, mean (range) | 42 (22–45) | 44 (40–47) | 0.152 |
| Male sex, N (%) | 251 (83.7) | 316 (88.0) | 0.115 |
| STEMI, N (%) | - | 212 (59.1) | - |
| NSTEACS, N (%) | - | 147 (40.9) | |
| NSTEMI, N (%) | - | 134 (37.3) | - |
| Unstable angina, N (%) | - | 13 (3.6) | - |
| Obesity, N (%) | 25 (8.3) | 124 (34.5) | <0.0001 |
| Hypertension, N (%) | 26 (8.7) | 218 (60.7) | <0.0001 |
| Diabetes, N (%) | 6 (2.0) | 74 (20.6) | <0.0001 |
| Dyslipidemia, N (%) | 61 (20.3) | 288 (80.2) | <0.0001 |
| Current smoking, N (%) | 41 (13.7) | 126 (35.1) | <0.0001 |
| rs2431697 genotype | |||
| CC, N (%) | 53 (17.7) | 60 (18.7) | 0.689 |
| CT, N (%) | 141 (47.0) | 154 (42.9) | 0.329 |
| TT, N (%) | 71 (23.7) | 105 (29.2) | 0.106 |
| C-allele, N (%) | 194 (64.7) | 214 (59.6) | 0.183 |
| T-allele, N (%) | 212 (70.7) | 261 (81.3) | 0.563 |
NSTEACS = non-ST segment elevation acute coronary syndromes; NSTEMI = non-ST segment elevation myocardial infarction; STEMI = ST segment elevation myocardial infarction. Genotype was available in 265 controls and in 321 ACS.