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. 2022 May 18;10:849854. doi: 10.3389/fcell.2022.849854

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Copyright © 2022 Pang, Liu, Wang, Shi, Ma, Zhang, Zhou, Zhao, Zhang, Fan, Hao, Li, Zhao, Zhang, Zhou, Kong, Feng and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Edaravone has a long-term effect on neuronal survival, reduced astrogliosis, and tissue sparing. (A) Representative images of immunofluorescence staining of NeuN in the injury epicenter of 8 weeks post SCI (B) Quantifications of NeuN. (C) Representative images of H&E staining of spinal cord sections at 4 weeks post injury. (D) Quantification of cavity areas made by ImageJ. Data are expressed as mean ± standard deviation. Statistical significance was determined by one-way ANOVA with Tukey’s post hoc test. *p < 0.05, and ***p < 0.001, n = 3, bar = 100 μm (A), bar = 500 μm (C).