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. 2022 May 18;10:849854. doi: 10.3389/fcell.2022.849854

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Copyright © 2022 Pang, Liu, Wang, Shi, Ma, Zhang, Zhou, Zhao, Zhang, Fan, Hao, Li, Zhao, Zhang, Zhou, Kong, Feng and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Edaravone promotes motor functional recovery after spinal cord injury. (A) Timeline of the experiment. 30 min after SCI, rats received EDV (5 mg/kg/day) continuously for 7 days. BBB scores were assessed every week for 8 weeks. In addition, Catwalk and MEP detection were performed at 8 weeks after SCI. (B) BBB locomotor scores were assessed for hindlimbs, up to 8 weeks post injury. (C) BBB scores at 8 weeks were compared. (D) Print views were recorded at 8 weeks post injury by the CatWalk XT system. (E) Regularity index (% index) is presented as an overall measure of the degree of the normal step sequence. (F) Electrophysiology of MEP at 8 weeks post spinal cord injury. (G) MEP amplitudes of each group were quantified. Data are expressed as the mean ± standard deviation. Statistical significance was determined by one-way ANOVA with Tukey’s post hoc test. *p < 0.05; **p < 0.01, n = 3.