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. 2022 May 18;10:849854. doi: 10.3389/fcell.2022.849854

FIGURE 8.

FIGURE 8

Schematic diagram of edaravone’s neuroprotective mechanism in spinal cord injury. Edaravone upregulates anti-ferroptosis protein GPX4 and xCT and downregulates pro-ferroptosis protein ACSL4 and 5-LOX. This leads to neuronal survival as well as reduced neuroinflammation, and improves recovery of SCI.