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Schematic representation of PYRIN activation in wild-type and mutated conditions. (A) In wild-type conditions phosphorylated PYRIN is kept inactive by inhibitory proteins; once phosphorylation is lost, i.e., due to bacterial invasion, the link between PYRIN and inhibitory proteins fails and PYRIN inflammasome becomes fully active. (B) Mutated PYRIN has an unstable link with the inhibitory proteins and the PYRIN inflammasome tends to activation.
