Table 5.

Cytotoxic activity of essential oils from species found in the Amazon.

Species	Botanic Family	Methodos	Results	References
Anaxagorea brevipes	Anonnaceae	SRB assay	MCF-7 = TGI 12.8 μg/mL)	[15]
			NCI-H460 = (TGI 13.0 μg/mL)
			PC-3 = TGI 9.6 μg/mL)
Eugenia cuspidifolia	Myrtaceae	Alamar blue assay	(MCF7) = IC50 18.11 μg mL−1	[29]
			(HCT116) = IC50 15. 25 μg mL−1
			(SK-MEL-19) = IC50 26.17 μg mL−1
			(ACP02) = IC50 > 50 μg mL−1
			(MRC-5) = IC50 25.51 μg mL−1
E. egensis	Myrtaceae	MTT colorimetric assay	HCT-116 = IC50 > 25 µg/mL	[30]
			SKMEL19 = IC50 > 25 µg/mL
			AGP-01 = IC50 > 25 µg/mL
E. flavescens	Myrtaceae		HCT-116 = IC50 13.9 µg/mL	[30]
			SKMEL19 = ****
			AGP-01 = ****
E. patrisii	Myrtaceae		MCF7 = ****	[32]
			SKMEL-19 = IC50 5.80 μg/mL
			AGP01 = IC50 3.21 μg/mL
			HCT116 = IC50 6.70 μg/mL
			MRC5 = IC50 3.5 μg/mL
E. patrisii	Myrtaceae		HCT-116 = IC50 16.4 µg/mL	[30]
			SKMEL19 = ****
			AGP-01 = ****
E. polystachya	Myrtaceae		HCT-116 = IC50 10.3 µg/mL	[30]
			SKMEL19 = ****
			AGP-01 = ****
E. stipitata	Myrtaceae		MCF7 = IC50 19.10 μg/mL	[32]
			SKMEL-19 = IC50 17.20 μg/mL,
			AGP01 = ****
			HCT116 = ****
			MRC5 = IC50 13.8 μg/mL
E. tapacumensis	Myrtaceae	Alamar blue assay	(MCF7) = IC50 24.35 μg mL−1	[29]
			(HCT116) = IC50 12.37 μg mL−1
			(SK-MEL-19) = IC50 > 50 μg mL−1
			(ACP02) IC50 > 50 μg mL−1
			(MRC-5) = IC50 36.12 μg mL−1
E. uniflora	Myrtaceae	MTT colorimetric assay	HCT-116 (IC50 E2: 16.26 μg/mL; IC50 E4: 9.28 μg/mL)	[90]
			AGP-01, (IC50 E2: 12.60 μg/mL; IC50 E4: 8.73 μg/mL)
			SKMEL-19 (IC50 E2: 12.20 μg/mL; IC50 E4: 15.42 μg/mL)
			MRC-5 (IC50 E2: 10,27 μg/mL; IC50 E4: 14.95 μg/mL)
Iryanthera polyneura	Myristicaceae	SRB assay	PC-3 = IC50 14.69 ± 4.33 μg/mL	[39]
			MCF-7 = IC50 13.63 ± 3.23 μg/mL
Myrcia splendens	Myrtaceae	MTT colorimetric assay	MCF7 = ****	[32]
			SKMEL-19 = IC50 8.50 μg/mL
			AGP01 = IC50 4.70 μg/mL
			HCT116 = IC50 8.80 μg/mL
			MRC5 = IC50 6.5 μg/mL
M. splendens	Myrtaceae		A549 = IC50 54.28 ± 2.39 µg/mL	[46]
			MCF-7 = IC50 1.24 ± 0.03 µg/mL
			HaCaT = IC50 10.15 ± 0.35 µg/mL
M. sylvatica	Myrtaceae		MCF7 = IC50 > 25 μg/mL	[32]
			SKMEL-19 = IC50 20.01 μg/mL
			AGP01 = IC50 17.31 μg/mL
			HCT116 = ****
			MRC5 = IC50 23.3 μg/mL
Nectandra cuspidata	Lauraceae		MCF-7 = IC50 117.1 ± 11.9 μg mL−1	[47]
N. puberula			MCF-7 = IC50 64.5 ± 1.6 μg mL−1
Piper anonifolium	Piperaceae		HCT-116 = IC50 > 25 µg/mL	[12]
			ACP-03 = IC50 > 25 µg/mL
			SKMEL19 = IC50 > 25 µg/mL
P. aleyreanum			HCT-116 = IC50 > 25 µg/mL
			ACP-03 = IC50 > 25 µg/mL
			SKMEL19 = IC50 = 7.4 μg/mL
P. hispidum			HCT-116 = IC50 > 25 µg/mL
			ACP-03 = IC50 > 25 µg/mL
			SKMEL19 = IC50 > 25 µg/mL
Psidium guajava	Myrtaceae		MCF7 = IC5012.41 μg/mL	[32]
			SKMEL-19 = IC50 15.31 μg/mL
			AGP01 = IC50 16.31 μg/mL
			HCT116 = ****
			MRC5 = IC50 20.8 μg/mL
P. guineense (Pgui-1)			MCF7 = IC50 11.60 μg/mL
			SKMEL-19 = IC50 11.10 μg/mL
			AGP01 = IC50 8.21 μg/mL
			HCT116 = ****
			MRC5 = IC50 8.27 μg/mL
P. guineense (Pgui-2)			MCF7 = IC50 18.21 μg/mL
			SKMEL-19 = IC50 19.11 μg/mL
			AGP01 = IC50 15.71 μg/mL
			HCT116 = ****
			MRC5 = 24 μg/mL
Virola surinamensis	Myristicaceae	SRB assay	Bark EO	[62]
			IC50 9.41 μg/mL (HCT116), 16.93 μg/mL (HepG2), 20.64 μg/mL (HL-60), 29.52 μg/mL (B16–F10), 15.88 μg/mL (MCF-7) and 34.07 μg/mL (MRC-5).
			Leaves EO
			IC50 26.70 μg/mL (HCT116), 7.07 μg/mL (HepG2), 22.76 μg/mL (HL-60), 18.80 μg/mL (B16–F10), 21.39 μg/mL (MCF-7) and 38.93 μg/mL (MRC-5)

MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). **** = statistically similar at 95% confidence level by Tukey’s test.