Figure 4.

Interaction networks and biological processes regulated by calcitriol, curcumin or their combination involved in the anti-VM effect of the compounds. STRING analysis of deregulated kinases in calcitriol (A) or curcumin (B) treated co-cultures. Images in (A,B) show the physical and functional protein interactions. Protein names in italics represent the top predicted interactors of the network. (C) Prediction of the biological processes differentially regulated in each treatment group. A total of 227 processes were co-regulated by calcitriol (CAL) and curcumin (CUR); 24 processes were shared by the CAL and CAL+CUR (C+C), and 124 were shared in the CUR and C+C groups. Inside each circle, the main pathways involved are depicted. Outside, near each circle, the biological processes in which protein complexes were predicted to participate are shown.