Table 1.
Baseline patient characteristics.
| CHE/ICIs (N = 76) | CHE (N = 74) | CHE/BEV (N = 33) | Total (N = 183) | p-Value | |
|---|---|---|---|---|---|
| Age—years old | |||||
| Median | 62.1 | 64.1 | 63.1 | 63.1 | |
| Range | 31–81 | 47–76 | 47–77 | 31–81 | |
| Sex (%) | 0.278 | ||||
| Male | 63 (82.9%) | 65 (87.8%) | 31 (93.9%) | 159 (86.9%) | |
| Female | 13 (17.1%) | 9 (12.2%) | 2 (6.1%) | 24 (13.1%) | |
| Disease stage (%) | 0.094 | ||||
| III | 18 (23.7%) | 15 (20.3%) | 2 (6.1%) | 35 (19.1%) | |
| IV | 58 (76.3%) | 59 (79.7%) | 31 (93.9%) | 148 (80.9%) | |
| Smoking status (%) | 0.569 | ||||
| More than 20 pack-years | 43 (56.6%) | 44 (59.5%) | 16 (48.5%) | 100 (54.6%) | |
| Less than 20 pack-years | 33 (43.4%) | 30 (40.5%) | 17 (51.5%) | 83 (45.4%) | |
| Lesion location | 0.630 | ||||
| Upper left | 20 (26.3%) | 25 (33.8%) | 13 (39.4%) | 58 (31.7%) | |
| Lower left | 9 (11.8%) | 10 (13.5%) | 2 (6.1%) | 21 (11.5%) | |
| Upper right | 32 (42.1%) | 26 (35.1%) | 12 (36.4%) | 70 (38.3%) | |
| Right middle | 5 (6.6%) | 1 (1.4%) | 1 (3.0%) | 7 (3.8%) | |
| Lower right | 10 (13.2%) | 12 (16.2%) | 4 (12.1%) | 26 (14.2%) | |
| ECOG PS score (%) | 0.209 | ||||
| 0 | 33 (%) | 24 (32.4%) | 16 (48.5%) | 73 (39.9%) | |
| 1 | 43 (%) | 50 (67.6%) | 17 (51.5%) | 110 (60.1%) | |
| Histologic type (%) | 0.174 | ||||
| Adenocarcinoma | 59 (77.6%) | 61 (82.4%) | 31 (93.9%) | 151 (82.5%) | |
| Squamous carcinoma | 3 (3.9%) | 3 (4.1%) | 0 (0%) | 6 (3.3%) | |
| NSCLC not otherwise specified (NSCLC-NOS) | 14 (18.4%) | 8 (10.8%) | 2 (6.1%) | 22 (12.0%) | |
| Neuroendocrine carcinoma | 0 (0%) | 2 (2.7%) | 0 (0%) | 2 (1.1%) | |
| Metastatic organ (%) | 0.847 | ||||
| Intrathoracic | 25 (32.9%) | 37 (50.0%) | 21 (63.6%) | 83 (45.4%) | |
| Brain | 10 (13.2%) | 8 (10.8%) | 9 (27.3%) | 27 (14.8%) | |
| Bone | 28 (36.8%) | 35 (47.3%) | 16 (48.5%) | 79 (43.2%) | |
| Adrenal gland | 11 (14.5%) | 6 (8.1%) | 5 (15.2%) | 22 (12.0%) | |
| Liver | 3 (4.0%) | 3 (4.1%) | 2 (6.1%) | 8 (4.4%) | |
| Others | 9 (11.8%) | 9 (12.2%) | 5 (15.2%) | 23 (12.6%) | |
| PD-L1 expression (%) | N = 56/76(73.7%) | N = 40/74(54.1%) | N = 18/33 (54.5%) | N = 114/183 (62.3%) | 0.003 |
| 0 | 12 (21.4%) | 11(27.5%) | 11 (61.1%) | 34 (29.8%) | |
| ≥1% | 44 (78.6%) | 29(72.5%) | 7 (38.9%) | 80 (70.2%) |