Table 5.
Glycated hemoglobin (HbA1c) among DMT2 patients grouped by treatment and genotype.
| Gene | SNP | Genotype | Metformin (%HbA1c) Median (IQR 25–75%) (n) |
Metformin + Glibenclamide (%HbA1c) Median (IQR 25–75%) (n) |
* p = |
|---|---|---|---|---|---|
|
SLC22A1 (OCT1) |
rs72552763 | GAT/GAT | 6 (5.7–6.8) (28) ¥ | 9.4 (8.5–11.2) (16) | <0.001 * |
| del/GAT | 6.5 (6.2–9.2) (22) | 8.3 (7.3–10.4) (24) | 0.023 * | ||
| del/del | 6.5 (6.4–6.8) (9) | 10.1 (8.4–11.3) (4) | 0.045 * | ||
| p = | 0.022 κ | 0.221 | |||
| rs622342 | A/A | 6 (5.8–6.5) (25) | 9.4 (8.5–11.2) (16) | <0.001 * | |
| A/C | 6.4 (6.1–7.7) (19) | 8.7 (7.5–10.9) (21) | 0.001 * | ||
| C/C | 6.8 (6.4–9.3) (15) ¥ | 8.3 (7.1–9.8) (7) | 0.397 | ||
| p = | 0.009 κ | 0.332 | |||
|
SLCA22A2 (OCT2) |
rs316019 | C/C | 6.4 (5.9–7.2) (52) | 9 (7.6–10.9) (42) | <0.001 * |
| A/C | 6.2 (5.8–8.1) (6) | 8.4 (7.3–9.5) (2) | 0.180 | ||
| A/A | 8.1 (1) | (0) | - | ||
| p = | 0.818 | 0.573 | |||
|
SLC22A3 (OCT3) |
rs2076828 | C/C | 6.3 (5.9–6.9) (46) | 8.9 (7.5–10.5) (32) | <0.001 * |
| C/G | 6.4 (5.9–8.2) (11) | 9.9 (7.7–12.2) (10) | 0.022 * | ||
| G/G | 8.6 (6.6–10.7) (2) | 8.6 (7.3–9.9) (2) | 1.000 | ||
| p = | 0.336 | 0.452 | |||
| ABCB1 | rs1128503 | C/C | 6.1 (5.7–6.3) (15) | 10.1 (9–11.8) (12) | <0.001 * |
| C/T | 6.6 (6.2–8.4) (28) ¥ | 8.5 (7.5 -10.5) (17) | 0.007 * | ||
| T/T | 6.2 (5.9–6.7) (16) | 8.5 (7.3–10.1) (15) | 0.007 * | ||
| * p = | 0.021 κ | 0.056 | |||
| rs2032582 | G/G | 6.1 (5.7–6.3) (19) | 9.9 (8.2–11.1) (15) | <0.001 * | |
| G/T | 6.8 (6.4–8.1) (27) ¥ | 8.6 (7–9.4) (16) | 0.058 | ||
| T/T | 6.2 (6–6.3) (9) | 8.8 (7.4–10.1) (8) | 0.002 * | ||
| T/A | 14.9 (1) | 8.3 (1) | - | ||
| G/A | 6.5 (6.2–7.4) (3) | 11 (10.9–13.3) (3) | 0.050 | ||
| * p = | 0.009 κ | 0.156 | |||
| rs1045642 | C/C | 6.1 (5.9–6.6) (17) | 9.9 (7.9–10.9) (19) | <0.001 * | |
| C/T | 6.5 (6.1–8.1) (29) | 8.7 (7.3–9.4) (17) | 0.024 * | ||
| T/T | 6.2 (6.1–6.4) (13) | 8.8 (8–10.1) (8) | 0.001 * | ||
| * p = | 0.160 | 0.511 | |||
| CYP2C9 | rs1799853 (*2) rs1057910 (*3) | *1/*1 | 6.4 (5.9–7.3) (50) | 9.2 (7.5–10.7) (35) | <0.001 * |
| *1/*2 | 6.2 (5.5–6.5) (6) | 8.8 (6.7–10.7) (4) | 0.165 | ||
| *2/*2 | (0) | (0) | - | ||
| *1/*3 | 8.3 (7.2–8.4) (3) | 8.3 (7–10.6) (4) | 1.000 | ||
| *2/*3 | (0) | 11 (1) | - | ||
| * p = | 0.352 | 0.811 | |||
| rs1934969 | A/A | 6.4 (6.1–7.6) (35) | 8.7 (7.5–11) (34) | <0.001 * | |
| A/T | 6.5 (5.9–7.3) (19) | 9.4 (8–10.2) (8) | 0.003 * | ||
| T/T | 6.2 (6–6.2) (5) | 10.4 (10.3–10.5) (2) | 0.051 | ||
| * p = | 0.808 | 0.611 |
* p < 0.05 for Mann–Whitney U-test. κ p < 0.05 for Kruskal–Wallis test. ¥ p < 0.05 for post-hoc test between genotypes.