Table 8.
Daily metformin dose mg/kg/day according to treatment and genotype.
| Gene | SNP | Genotype | Metformin (mg/kg/day) Median (IQR 25–75%) (n) |
Metformin + Glibenclamide (mg/kg/day) Median (IQR 25–75%) (n) |
p = |
|---|---|---|---|---|---|
| ABCB1 | rs1128503 | C/C | 18.78 (12.28–25.41) (14) | 26.98 (18.19–34.53) (12) | 0.057 |
| C/T | 19.12 (11.92–26.08) (27) | 29.27 (23.16–35.31) (17) | 0.001 * | ||
| T/T | 20 (11.78–24.42) (15) | 29.7 (16.66–31.95) (14) | 0.127 | ||
| p = | 0.969 | 0.971 | |||
| rs2032582 | G/G | 16.48 (11.93–23.28) (17) | 26.98 (21.35–32.04) (15) | 0.011 * | |
| G/T | 19.78 (12.99–27.33) (26) | 24.35 (15.34–32.83) (16) | 0.170 | ||
| T/T | 20 (16.48–21.19) (9) | 31.95 (29.77–29.15) (7) | 0.064 | ||
| T/A | 27.82 (1) | 29.51 (1) | - | ||
| G/A | 10.24 (10.02–10.85) (3) | 32.11 (28.44–34.03) (3) | 0.050 | ||
| p = | 0.118 | 0.356 | |||
| rs1045642 | C/C | 12.29 (11–22.65) (16) | 27.86 (23.21–33.71) (19) | 0.001 * | |
| C/T | 19.56 (12.93–27.39) (27) | 25.55 (16.66–30.35) (17) | 0.152 | ||
| T/T | 20 (14.5–21.19) (13) | 37.5 (29.77–39.71) (7) | 0.019 * | ||
| p = | 0.298 | 0.156 |
* p < 0.05 for Mann–Whitney U-test