Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 12;12:852902. doi: 10.3389/fcimb.2022.852902

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Cortazzo da Silva, Aoki and Floeter-Winter

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Leishmania life cycle in mammalian and insect hosts. The differentiation processes involve drastic changes in pH, temperature, and nutrient availability, challenging the parasite’s ability to orchestrate its gene expression accordingly. Metacyclogenesis is essentially represented in the right portion of the figure, comprising the differentiation from procyclic into nectomonad and then into leptomonad and metacyclic forms inside the sandfly digestive tract. Amastigogenesis is represented in the left portion of the figure, comprising the differentiation from metacyclic promastigote to amastigote forms inside the mammalian host macrophage. N, Macrophage Nucleus; PV, Parasitophorous Vacuole.