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. 2022 Jul 19;10(7):1149. doi: 10.3390/vaccines10071149

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Safety evaluation of Omicron vaccine. (A,B) Acute toxicity experiment. Effects of acute toxicity on body weight and food intake of SD rats, n = 10 in each group, 5/gender/group. (C,D) Active allergy experiment. Effect of systemic active allergy experiment on the body weight of guinea pigs. Incidence of adverse reactions in active systemic hypersensitivity test 14 days and 21 days after the last sensitization of Omicron vaccine, and n = 9 in each group. (E,F) Muscle stimulation experiment. Statistical chart of adverse reactions of New Zealand white rabbits in muscle stimulation experiment, and (F) histopathological sections of adverse reactions, n = 8 in each group. Error bars represent SEM. * p < 0.05.