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Predicted water solubility and additional pharmacokinetic properties of the two most promising putative NAPRT inhibitors.
| Compound ID | Log S (ESOL) |
Log S (Ali) |
Log S (SILICOS-IT) |
GI Absorption | Pgp Substrate | BBB Permeant | Bioavailability Score |
|---|---|---|---|---|---|---|---|
| 2-HNA | −1.65 | −1.97 | −0.8 | High | No | No | 0.85 |
| 8 | −1.44 | −1.62 | −0.8 | High | No | No | 0.85 |
| 19 | −1.18 | −1.77 | −0.26 | High | No | No | 0.56 |
