Figure 2.

Functionalization patterns in active compounds evaluated for MDR. (A) Functionalization patterns in 5,6-epoxylathyranes; (B) Functionalization patterns in 6,17-epoxylathyranes; (C) Functionalization patterns in Δ^5,6 lathyranes; (D) Functionalization patterns in Δ^6,17 lathyranes. As discussed in the text, these are not absolute rules, as exceptions are observed. Both conformation of lathyrane macrocyclic scaffold and substitution patterns are determinants for MDR activity [22]. * Electron withdrawing groups and steric hindrance is detrimental for the activity of compounds evaluated against drug efflux transporters in Candida albicans.