Figure 1.

Experimental scheme developed to assess the effects of quercetin using both in vivo and in vitro models. Wild-type C57BL/6J mice and New Zealand white rabbit models were used to observe scar development following topical quercetin or vehicle application. The 3D corneal stromal model was generated using primary human corneal fibroblasts cultured for 4 weeks in vitro to promote the deposition of a self-assembled stromal matrix.