Figure 1.

Baseline spontaneous GABAergic transmission in central amygdala (CeA) of males and females. (A–E): (A) Representative GABA_A-mediated sIPSCs from CeA neurons of male (left) and female (right) rats, either naïve (upper) or alcohol dependent (lower). There is no effect of Sex or Alcohol Exposure and no interaction effect in CeA baseline sIPSC frequency (B), amplitude (C), or rise time (D). For sIPSC decay time (E), there is no main effect of Sex or interaction effect, but there is a main effect of Alcohol Exposure, primarily driven by dependent females with a prolonged decay time (10.88 ± 0.67 ms) compared to naïve females (8.24 ± 0.57 ms). Differences in baseline sIPSC properties are assessed using two-way ANOVA test.; Bars represent Mean ± SEM; *** denotes p < 0.001; n = 31–36 neurons per group; N = 19–25 rats per group.