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. 2022 Jul 17;15(7):881. doi: 10.3390/ph15070881

Table 2.

IC50 values of different drug groups against different TNBC cells.

Cell lines IC50 (µg/mL)
5-FU PTX 5-FU/PTX 5-FU/PTX Lps KLA-5-FU/PTX Lps
MDA-MB-231 7.66 ± 0.54 5.17 ± 0.51 2.97 ± 0.47 1.62 ± 0.23 0.85 ± 0.07
MDA-MB-453 9.54 ± 0.76 8.10 ± 0.74 4.44 ± 0.66 2.47 ± 0.12 2.10 ± 0.04
MDA-MB-436 6.24 ± 0.69 5.35 ± 0.72 2.14 ± 0.18 1.64 ± 0.15 1.24 ± 0.06

All preparations were tested in triplicate. IC50, half-maximal inhibitory concentration. 5-FU, 5-fluorouracil; PTX, paclitaxel; 5-FU/PTX, mechanically mixed free 5-FU and free PTX; 5-FU/PTX Lps, unmodified liposomes co-loaded with 5-FU and PTX; KLA-5-FU/PTX Lps, KLA-modified liposomes co-loaded with 5-FU and PTX.