Table 2.
Cell lines | IC50 (µg/mL) | ||||
---|---|---|---|---|---|
5-FU | PTX | 5-FU/PTX | 5-FU/PTX Lps | KLA-5-FU/PTX Lps | |
MDA-MB-231 | 7.66 ± 0.54 | 5.17 ± 0.51 | 2.97 ± 0.47 | 1.62 ± 0.23 | 0.85 ± 0.07 |
MDA-MB-453 | 9.54 ± 0.76 | 8.10 ± 0.74 | 4.44 ± 0.66 | 2.47 ± 0.12 | 2.10 ± 0.04 |
MDA-MB-436 | 6.24 ± 0.69 | 5.35 ± 0.72 | 2.14 ± 0.18 | 1.64 ± 0.15 | 1.24 ± 0.06 |
All preparations were tested in triplicate. IC50, half-maximal inhibitory concentration. 5-FU, 5-fluorouracil; PTX, paclitaxel; 5-FU/PTX, mechanically mixed free 5-FU and free PTX; 5-FU/PTX Lps, unmodified liposomes co-loaded with 5-FU and PTX; KLA-5-FU/PTX Lps, KLA-modified liposomes co-loaded with 5-FU and PTX.