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. 2022 Jun 28;14(7):1415. doi: 10.3390/v14071415

Figure 6.

Figure 6

Structural mimicry between an ELDKY motif in SARS-CoV-2 Spike and epitopes in six other proteins. (a) Sequence alignment between SARS-CoV-2 Spike and the epitopes containing the 3D-mimicry motif for human kynureninase (hKYNU, IEDB Epitope ID: 1007556), respiratory syncytial virus fusion F0 glycoprotein (RSV F0, IEDB Epitope ID: 1087776), human cytoplasmic FMR1-interacting protein 1 (hCYFIP1, IEDB Epitope ID: 1346528), human tight junction-associated protein 1 (hTJAP1, IEDB Epitope ID: 1016424), human keratin type I cytoskeletal 18 (hKRT18, IEDB Epitope ID: 1331545), and human tropomyosin alpha-3 (hTPM3, IEDB Epitope ID: 938472). Residues in the molecular mimicry motifs are colored by Taylor [65]. The extended molecular mimicry region is highlighted by the orange dashed box. (b) Surface representation of Spike (PDB id: 6XR8) colored by subunit (beige, pink, light blue) with ELDKY motif indicated in red. Surface representation of proteins (gray) with full or partial 3D-mimics of the ELDKY motif (red): (c) hKYNU (PDB id: 2HZP), (d) RSV F0 (PDB id: 6EAE), (e) hCYFIP1 (PDB id: 4N78), (f) hTJAP1 (Uniprot: Q5JTD0), (g) hKRT18 (Uniprot: P05783), (h) hTPM3 (Uniprot: P06753). Alignment representations were generated with Jalview 2.11.2.2 [66] and structural visualizations were generated with PyMOL 2.5.0 [30].