Figure 2.

Illustrative representation of human TIAR isoforms and gene. Collection of exons and introns of the main isoforms, a and b, generated by alternative splicing, as well as functional domains. TIAR contains three RNA-recognition motifs (RRMs) and an auxiliary domain IDR rich in asparagine and glutamine (Q/N-rich domain). The location and position of amino acid sequences on RRM1 that differentiate the a and b isoforms is shown above a spacer. The secondary–tertiary structures of each of the three RRMs are shown.