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. 2022 Jul 1;14(7):1398. doi: 10.3390/pharmaceutics14071398

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Visualization of EpiDerm™ surface 24 h after treatment. Comparison of silver nanoparticles (AgNP), graphene oxide (GO), and AgNP-GO complex activity to the negative control (NC, DPBS) and positive control (PC, SDS). (A) Digital photos of EpiDerm™ without fixation were obtained using a stereo microscope. (B) Tissues imaged in a scanning electron microscope were fixed in 2.5% l-glutaraldehyde in PBS. White arrows indicate the places of exfoliation and keratinization of the top layer; yellow arrows indicate a disruption of the continuity of the tissue surface.