Table 1.
The table shows the demographic and clinical characteristics of the 2 patients on admission. Laboratory and imaging findings on admission as well as treatments administered during the hospitalization in both patients are also shown.
| Title | Patient 1 | Patient 2 |
|---|---|---|
| Age (years) | 14 | 9 |
| Sex | F | M |
| Initial central nervous system Manifestations |
Episode of unresponsiveness to stimuli, catatonia, inability to move followed by agitation and confusion | Agitation and headache, followed by drowsiness |
| Others symptoms | Fever, vomit | Fever, conjunctivitis, palmar rash, vomiting, diarrhea, abdominal pain |
| Laboratory findings | ||
| White blood cell (103/uL) | 11.87 | 5.06 |
| Neutrophils (103/uL) | 10.03 | 4.20 |
| Lymphocytes (103/uL) | 0.74 | 0.44 |
| Platelet (103/uL) | 314 | 55 |
| CRP (mg/dL) (N < 0.50) | 26.77 | 16 |
| Procalcitonin (ng/mL)(N: 0–0.5) | 4.18 | 9.96 |
| Ferritin (mg/L)(N: 13–150) | 501 | 1374 |
| Troponin I (pg/mL)(N: <14) | 25.7 | 66.1 |
| Pro-BNP (pg/L)(N: <217) | 320 | 9865 |
| Fibrinogen (mg/dL)(N: 212–433) | 700 | 552 |
| D-dimer (mcg/mL) | 8.18 | 5.35 |
| Albumin (g/dl) | 3.1 | 3.3 |
| Natrium (mEq/L) | 127 | 129 |
| AST (U/L) | 46 | 70 |
| ALT (U/L) | 54 | 32 |
| Creatinine (mg/dl) | 1.26 | 1.17 |
| ACTH (pg/mL) | 228 | |
| CSF | ||
| Glucose (mg/dL) | 97 | |
| Protein (mg/dL) | 20 | |
| Cell count (/mm3) | 2 | |
| Echocardiogram | Normal ventricular systolic functions | Left ventricular ejection fraction 44% |
| Chest X-ray | Normal at the admission Day 3: right pleural effusion |
Mild accentuation of the broncovascular texture |
| EEG | global slowing | global slowing |
| Brain Imaging | MRI: hyperintensity on T2-weighted images in the splenium of the corpus callosum with restricted diffusion | MRI: hyperintensity on T2-weighted images in the splenium of corpus callosum with restricted diffusion |
| Immune treatment | IVIG Steroid therapy |
IVIG Steroid therapy Anakinra |
| Other treatment | Oxygen | Milrinone |
| Enoxaparin | Enoxaparin | |
| Diuretic | Diuretic |
Abbreviations: MRI: Magnetic resonance imaging; IVIG: Intravenous Immunoglobulins.