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. 2022 Jul 16;14(14):3458. doi: 10.3390/cancers14143458

Figure 2.

Figure 2

Core-clock manipulation affects EMT gene expression in SW480 and SW620 cells. Gene expression analysis of core-clock genes PER2, CRY1, NR1D1, CLOCK, and ARNTL as well as EMT-related genes in control and core-clock knockdown (shARNTL, shPER2 and shNR1D1, respectively) cell lines in SW480 (A) and SW620 (B) cells at 24 h after synchronization (n = 3, mean ± SEM). Heatmaps of Pearson correlations between each pair of core-clock and EMT-related genes for (C) SW480 and (D) SW620 shARNTL, shPER2 and shNR1D1 cells compared with the control cell line. * p < 0.05, ** p < 0.01, *** p < 0.001; two-tailed unpaired t-test.