Skip to main content
. 2022 Jul 10;14(14):3358. doi: 10.3390/cancers14143358

Table 1.

Characteristics of the 18 individual series included in the integrative meta-analysis.

GEO
Accession 		Samples (n) Year Platform Sample Characteristics Reference
Total BCa Controls
GSE3167 60 46 14 2005 GPL96
(HG-U133A) Affymetrix Human Genome U133A Array

  • 13 superficial transitional cell carcinomas with surrounding CIS

  • 15 without surrounding CIS lesions13 muscle-invasive carcinomas

  • 5 CISs

  • 5 CISs

  • 14 normal bladder tissues

 [82]
GSE7476 12 9 3 2007 GPL570
(HG-U133_Plus_2) Affymetrix Human Genome U133 Plus 2.0 Array

  • 3 groups of 5 pooled Ta tumors

  • 1 group of 5 pooled T1 tumors

  • 2 groups of 4 pooled T1 tumors

  • 3 groups of 5 pooled T2+ tumors

  • 3 groups of 4 pooled normal bladder tissues

 [83]
GSE13507 232 170 62 2010 GPL6102
Illumina human-6 v2.0 expression beadchip

  • 24 primary Ta cancer tissues

  • 62 primary T1 cancer tissues

  • 31 primary T2 cancer tissues

  • 19 primary T3 cancer tissues

  • 11 primary T4 cancer tissues

  • 23 recurrent NMIBC tissues

  • 62 normal bladder tissues

 [64]
GSE21142 24 12 12 2013 GPL10274
Affymetrix GeneChip Human Genome U133 Plus 2.0 Array
(Brainarray CustomCDF, GU133Plus2_Hs_UG_Version 12.cdf)

  • 6 superficial urothelial carcinomas

  • 6 invasive urothelial carcinomas

  • 12 normal bladder tissues

 [84]
GSE23732 8 7 1 2012 GPL6244
(HuGene-1_0-st) Affymetrix Human Gene 1.0 ST Array
(transcript (gene) version)

  • 7 muscle-invasive bladder cancer

  • 1 normal bladder tissue

 -
GSE24152 17 10 7 2010 GPL6791
Affymetrix GeneChip Human Genome U133 Plus 2.0 Array
(CDF: Hs_ENTREZG_10)

  • 10 muscle-invasive urothelial bladder carcinomas

  • 7 benign bladder tissues

 [85]
GSE31189 92 52 40 2013 GPL570
(HG-U133_Plus_2) Affymetrix Human Genome U133 Plus 2.0 Array

  • 52 urothelial cancer cells

  • 40 normal urothelial cells

 [86]
GSE37815 24 18 6 2013 GPL6102
Illumina human-6 v2.0 expression beadchip

  • 18 NMIBC tissues

  • 6 normal bladder tissues

 [87]
GSE38264 38 28 10 2014 GPL6244
(HuGene-1_0-st) Affymetrix Human Gene 1.0 ST Array
(transcript (gene) version)

  • 28 Ta and T1 tumors

  • 10 normal bladder tissues

 [88]
GSE40355 24 16 8 2013 GPL13497
Agilent-026652 Whole Human Genome Microarray 4x44K v2
(Probe Name version)

  • 8 Ta urothelial carcinoma tissues

  • 5 T1 urothelial carcinoma tissues

  • 3 T2 urothelial carcinoma tissues

  • 8 normal bladder tissue samples

 [89]
GSE41614 10 5 5 2013 GPL5175
(HuEx-1_0-st) Affymetrix Human Exon 1.0 ST Array
(transcript (gene) version)

  • 2 samples with blood vessels from T1 bladder cancer tissue

  • 2 samples with blood vessels from T2 bladder cancer tissue

  • 1 sample with blood vessels from T3 bladder cancer tissue

  • 5 samples with blood vessels from normal bladder

 [90]
GSE42089 18 10 8 2013 GPL9828
(HG-U133_Plus_2) Affymetrix Human Genome U133 Plus 2.0 Array (CDF: Brainarray Hs133P_Hs_ENTREZG version 10)

  • 10 urothelial cell carcinomas

  • 8 normal bladder tissues

 [91]
GSE45184 6 3 3 2013 GPL14550
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray
(Probe Name Version)

  • 3 bladder cancer tissues

  • 3 normal adjacent tissues

 [92]
GSE52519 12 9 3 2013 GPL6884
Illumina HumanWG-6 v3.0 expression beadchip

  • 1 T1 cancerous tissue sample

  • 2 T2 cancerous tissue samples

  • 2 T3 cancerous tissue samples

  • 4 T4 cancerous tissue samples

  • 3 normal bladder tissues

 [93]
GSE65635 12 8 4 2015 GPL14951
Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip

  • 5 T1 bladder cancer tissues

  • 2 T3 bladder cancer tissues

  • 1 T4 bladder cancer tissues

  • 4 normal bladder tissues

 [93]
GSE76211 6 3 3 2017 GPL17586
(HTA-2_0) Affymetrix Human Transcriptome Array 2.0
(transcript (gene) version)

  • 3 T3 bladder cancer tissues

  • 3 normal bladder tissues

 [94]
GSE100926 6 3 3 2017 GPL14550
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray
(Probe Name Version)

  • 2 T2 MIBC tissues

  • 1 T3 MIBC tissue

  • 3 normal bladder tissues

 [95]
GSE121711 18 8 10 2019 GPL17586
(HTA-2_0) Affymetrix Human Transcriptome Array 2.0
(transcript (gene) version)

  • 3 Ta primary tumors

  • 2 T1 primary tumors

  • 3 T2 primary tumors

  • 10 normal bladder tissues

 [96]
Total 619 417 202 -- -- -- --