Table 5.
Univariate Cox regression analysis of the survival-associated hub genes in BCa patients (HR: hazard ratio, CI: confidence interval, * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001, **** p-value < 0.0001).
| Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|
| RFS Related Gene | HR (95% CI) | p-Value | HR (95% CI) | p-Value |
| ACTG2 | 1.2 (1–1.4) | 1.40 × 10−2 * | -- | -- |
| AURKB | 2.1 (1.5–3) | 3.30 × 10−5 **** | -- | -- |
| BUB1 | 1.8 (1.2–2.6) | 1.90 × 10−3 ** | -- | -- |
| CDC25A | 3.1 (1.6–5.9) | 9.80 × 10−4 *** | -- | -- |
| CDT1 | 1.9 (1.4–2.6) | 1.00 × 10−4 *** | -- | -- |
| CENPM | 2.1 (1.4–3.1) | 1.90 × 10−4 *** | -- | -- |
| ESPL1 | 2.8 (1.7–4.6) | 5.30 × 10−5 **** | -- | -- |
| EXO1 | 3.8 (1.9–7.7) | 2.50 × 10−4 *** | -- | -- |
| GINS2 | 1.8 (1.2–2.5) | 1.40 × 10−3 ** | -- | -- |
| KIF20A | 1.8 (1.3–2.5) | 6.00 × 10−4 *** | -- | -- |
| COL3A1 | 1.5 (1.1–1.9) | 3.50 × 10−3 ** | 1.72 (1.29–2.29) | 0.000223 *** |
| COL4A5 | 0.66 (0.51–0.85) | 1.70 × 10−3 ** | -- | -- |
| LUM | 1.3 (1–1.6) | 1.80 × 10−2 * | -- | -- |
| SPP1 | 1.4 (1.1–1.7) | 4.80 × 10−3 ** | -- | -- |
| ASPM | 1.9 (1.4–2.6) | 5.40 × 10−5 **** | -- | -- |
| CCNA2 | 1.6 (1.2–2.3) | 2.50 × 10−3 ** | -- | -- |
| CCNB1 | 1.7 (1.1–2.6) | 1.00 × 10−2 * | -- | -- |
| CCNB2 | 1.8 (1.3–2.4) | 9.90 × 10−5 **** | -- | -- |
| CDC20 | 1.7 (1.3–2.3) | 1.90 × 10−4 *** | -- | -- |
| CDC45 | 2.7 (1.7–4.2) | 1.30 × 10−5 **** | -- | -- |
| CDCA8 | 2.2 (1.5–3.2) | 2.40 × 10−5 **** | -- | -- |
| CDKN3 | 2.1 (1.5–3) | 3.40 × 10−5 **** | -- | -- |
| CENPA | 1.8 (1.3–2.5) | 2.70 × 10−4 *** | -- | -- |
| CENPF | 2 (1.5–2.7) | 7.50 × 10−6 **** | -- | -- |
| CENPU | 1.7 (1.1–2.6) | 2.20 × 10−2 * | -- | -- |
| DLGAP5 | 1.7 (1.2–2.3) | 1.20 × 10−3 ** | -- | -- |
| ECT2 | 3 (1.5–6.2) | 3.00 × 10−3 ** | -- | -- |
| EZH2 | 2.2 (1.4–3.4) | 5.30 × 10−4 *** | -- | -- |
| FOXM1 | 2.7 (1.8–4) | 3.20 × 10−6 **** | 5.34 (2.95–9.64) | 2.87 × 10−8 **** |
| HJURP | 2.1 (1.5–2.9) | 4.30 × 10−5 **** | -- | -- |
| KIF11 | 1.9 (1.3–2.8) | 6.00 × 10−4 *** | -- | -- |
| KIF14 | 2.4 (1.5–3.7) | 1.40 × 10−4 *** | -- | -- |
| KIF23 | 3 (1.5–5.7) | 1.20 × 10−3 ** | -- | -- |
| MCM2 | 1.7 (1.2–2.3) | 1.70 × 10−3 ** | -- | -- |
| MCM4 | 1.4 (1–1.9) | 3.80 × 10−2 * | -- | -- |
| MKI67 | 9.8 (4–24) | 8.60 × 10−7 **** | -- | -- |
| NCAPG | 2.1 (1.5–3) | 6.40 × 10−5 **** | -- | -- |
| NDC80 | 1.5 (1.1–2.1) | 1.30 × 10−2 * | -- | -- |
| NEK2 | 2.5 (1.4–4.5) | 2.40 × 10−3 ** | -- | -- |
| PBK | 1.7 (1.2–2.4) | 2.50 × 10−3 ** | -- | -- |
| PLK4 | 1.6 (1–2.5) | 3.90 × 10−2 * | 0.38 (0.19–0.80) | 0.010188 * |
| RAD54L | 2.3 (1.5–3.4) | 4.40 × 10−5 **** | -- | -- |
| TOP2A | 1.5 (1.2–1.9) | 1.50 × 10−3 ** | -- | -- |
| TTK | 1.8 (1.3–2.4) | 5.50 × 10−4 *** | -- | -- |
| UBE2C | 2.3 (1.5–3.6) | 2.50 × 10−4 *** | -- | -- |
| ZWINT | 3 (1.4–6) | 3.00 × 10−3 ** | -- | -- |