Table 1.
Main clinical characteristics of patients harboring BRAF alterations detected through the analysis of the cBioPortal.
| Clinical Characteristics | Total (n = 236) |
Class 1 (n = 45) |
Class 2 (n = 48) |
Class 3 (n = 46) |
Undefined Class (n = 97) |
p Value |
|---|---|---|---|---|---|---|
| Age, Mean (SD) | 66.0 (9.4) | 66.6 (10.6) | 68.5 (9.6) | 65.7 (8.8) | 64.8 (8.9) | 0.243 |
| Sex, n (%) | ||||||
| Female | 118 (51.5) | 30 (68.2) | 22 (47.8) | 27 (58.7) | 39 (41.9) | 0.023 |
| Male | 111 (48.5) | 14 (31.8) | 24 (52.2) | 19 (41.3) | 54 (58.1) | |
| Histology, n (%) | ||||||
| Adenocarcinoma | 205 (86.9) | 45 (100.0) | 43 (89.6) | 41 (89.1) | 76 (78.4) | 0.005 |
| Squamous | 23 (9.7) | 0 (0) | 2 (4.2) | 3 (6.5) | 18 (18.6) | |
| Non-Small Cell Lung Cancer NOS | 8 (3.4) | 0 (0) | 3 (6.2) | 2 (4.3) | 3 (3.1) | |
| Geographical origin, n (%) | ||||||
| Caucasian | 65 (73.9) | 5 (45.5) | 13 (65.0) | 12 (100.0) | 35 (77.8) | 0.059 |
| Asian | 17 (19.3) | 5 (45.5) | 6 (30.0) | 0 (0) | 6 (13.3) | |
| African | 6 (6.8) | 1 (9.1) | 1 (5.0) | 0 (0) | 4 (8.9) | |
| Smoking habit, n (%) | ||||||
| Yes | 146 (83.4) | 21 (56.8) | 31 (93.9) | 36 (92.3) | 58 (87.9) | <0.001 |
| No | 29 (16.6) | 16 (43.2) | 2 (6.1) | 3 (7.7) | 8 (12.1) |
NOS: not otherwise specified.