Figure 2.

Parameters defining voltage-gated currents I_HTK, I_A, and I_H show considerable variability. A, Example voltage clamp recordings of high-threshold potassium currents [I_HTK, A1; arrows indicate the transient (t) and persistent (p) components], the transient potassium A current (I_A, A2) and the H current (I_H, A3). Double-arrow in A3 indicates the measured amplitude of I_H. B, Schematic diagram of fits in each experiment to the I_HTK and I_A conductances (g, measured by dividing current by the driving force, assuming E_K = −80 mV). Fits were used to calculate maximum conductance (g_max), half-activation voltage (V_1/2), and activation slope factor (k, measured from the slope of the dashed line). C, Maximal conductances of the transient and persistent components of I_HTK, I_A, and I_H across preparations. D, Half-activation voltage of the transient and persistent components of I_HTK and of I_A across preparations. E, Activation slope factor of the transient and persistent components of I_HTK and of I_A across preparations. Among these parameters, there were some pairwise correlations among the g_max values as well as the parameters V_1/2 and k (see Extended Data Fig. 2-1 for plots and Extended Data Fig. 2-2 for all p and R values).