Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 27;12(7):1563. doi: 10.3390/diagnostics12071563

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Case 6 was a 32-year-old woman with gastrointestinal stromal tumor (GIST) that displayed a sheet-like growth pattern with extensive hyalinization (A), composed of spindle cells (B) and uniform epithelioid cells (C) with the former arranged in a pattern analogous to Verocay bodies. Myxoid changes (D) were present in some areas. The most recent biopsy (108 months after the initial diagnosis) showed a recurrent GIST with epithelioid morphology (E) with diffuse c-KIT expression (F). Next-generation sequencing revealed a pathogenic RB1 p.R355fs mutation (G, right) in the most recent biopsy specimen but not in the primary (G, left) or previous recurrent tumors. Original magnification: (A), ×40; (B,D,E), ×200; (C,F), ×400.

Case 6 was a 32-year-old woman with gastrointestinal stromal tumor (GIST) that displayed a sheet-like growth pattern with extensive hyalinization (A), composed of spindle cells (B) and uniform epithelioid cells (C) with the former arranged in a pattern analogous to Verocay bodies. Myxoid changes (D) were present in some areas. The most recent biopsy (108 months after the initial diagnosis) showed a recurrent GIST with epithelioid morphology (E) with diffuse c-KIT expression (F). Next-generation sequencing revealed a pathogenic RB1 p.R355fs mutation (G, right) in the most recent biopsy specimen but not in the primary (G, left) or previous recurrent tumors. Original magnification: (A), ×40; (B,D,E), ×200; (C,F), ×400.