Table 1.
Clinicopathological features.
| Case | Age and the Year at the Original Diagnosis | Clinical Presentation | Surgical Procedure * | Site and Size of Primary Tumor | Gynecologic Organ Involvement | Patient Outcome |
|---|---|---|---|---|---|---|
| 1 | 56 (2019) | Abdominal pain and pelvic mass | TAH, LSO, small bowel resection, omental biopsy | Ileum, 12.6 cm | Not involved | 16 months with tumor debulking (multiple pelvic mass, largest 8.4 cm); 29 months with residual disease, on Imatinib |
| 2 | 59 (2006) | Abdominal pain and omental/pelvic mass | TAH, LSO, small bowel and colon resection, OMT | Multiple mass lesions involving small bowel, colon, bladder, and pelvis; largest 21.3 cm | Uterus involved | Diagnosed with small bowel GIST at age 59 and managed conservatively with Imatinib. Debulking procedure was performed at age 72. Currently on palliation |
| 3 | 62 (2006) | Pelvic mass | TAH, BSO, small bowel resection, liver segmental resection, CCY | Small bowel, 4.7 cm | Not involved | No residual GIST. The patient developed acute myeloid leukemia (ALL) at age 76. Died of ALL at age 77 |
| 4 | 80 (2009) | Abdominal pain and pelvic mass | TAH, BSO, small bowel resection, OMT, APPY | Multiple mass lesions involving small bowel, peritoneum and omentum; largest 14 cm | Left ovary involved by microscopic focus of metastatic GIST | Died at age 87 |
| 5 | 53 (2012) | Pelvic mass | TAH, BSO, small bowel and sigmoid colon resection, OMT | Multiple mass lesions involving small bowel, peritoneum and omentum; largest 20 cm | Bilateral ovaries involved by metastatic GIST | NA |
| 6 | 32 (2013) | Pelvic mass | Tumor debulking, APPY, OMT | Multiple mass lesions involving jejunum, mesentery, bladder, appendix; largest 2.7 cm | Bilateral ovaries involved by metastatic GIST | Recurrent at the age 40. Currently (41 years old) on sunitinib |
| 7 | 45 (2011) | Pelvic mass | Tumor debulking, small bowel resection, APPY, OMT, BSO | Multiple mass lesions involving small bowel, mesentery, rectum; largest 10 cm | Not involved | Recurrent at the age 49. Currently (56 years old) on palliation |
| 8 | 44 (2019) | Right pelvic mass | TAH, bilateral ovarian cystectomy, tubal ligation, tumor excision | 2 mass lesions (6.5 cm and 5.3 cm) involving ileum and broad ligament | Not involved | NA |
| 9 | 51 (2020) | Pelvic mass | Excision and APPY | 17 cm, attached to small bowel and sigmoid colon | Not involved | NA |
| 10 | 83 (2011) | Pelvic mass | Small bowel resection, OMT, APPY | Multiple mass lesions involving small bowel, omentum, bladder peritoneum; largest 14.5 cm | Not involved (history of TAH and BSO for benign lesion) | 30 months, died of disease |
| 11 | 53 (2021) | Pelvic mass | Small bowel resection, omental biopsy, APPY, myomectomy, bilateral salpingectomy | 22.5 cm solid and cystic mass arising from the wall of the small bowel; status post neoadjuvant treatment | Not involved | 4 months, no evidence of disease |
| 12 | 36 (2020) | Pelvic mass | TAH, BSO, OMT | 27 cm mass focally attached to the proximal ileum | Not involved | 14 months, no evidence of disease |
| 13 | 33 (2016) | Pelvic mass | Small bowel resection, tumor debulking, APPY, CCY | 27 cm small bowel mass with intraperitoneal spread | Not involved | 52 months, no evidence of disease |
| 14 | 47 (2017) | 9 cm posterior vaginal mass, between rectum and vagina | Biopsy | Rectum; 9 cm by imaging | Vagina | NA |
| 15 | 52 (2008) | Pelvic mass | Colectomy | Rectum; 6.4 cm | Posterior vagina | 161 months, multiple recurrence, currently disease progression |
| 16 | 70 (2012) | Anorectal mass | Rectum resection, TAH, BSO | Rectum; 12 cm | Not involved | 17 months, no evidence of disease |
| 17 | 48 (2008) | Pelvic mass; history of GIST | Partial gastrectomy, liver segmental resection, CCY, TAH, RSO | Stomach, 7 cm | Uterus involved by metastatic GIST | Gastric GIST with multiple recurrence involving liver, omentum, diaphragm, pelvic sidewall, uterus, sacrum, and rectus. Died of disease at age 57 |
| 18 | 23 (2018) | Abdominal pain and omental/pelvic mass | OMT, CCY, partial gastrectomy | Stomach origin; multiple mass lesions involving omentum and pelvic cul-de-sac; largest 3.5 cm | Not involved | 36 months, no evidence of disease |
| 19 | 41 (2005) | Pelvic mass; history of GIST | Partial gastrectomy, liver segmental resection, CCY, TAH, BSO | Stomach, 7 cm; liver metastasis; involving gallbladder, mesentery, pelvic sidewall | Not involved | 76 months, multiple recurrence, last follow-up with disease progression |
| 20 | 66 (2019) | Left pelvic mass; history of GIST | Excision | 9 cm, unknown primary site | Unknown | NA |
APPY: appendectomy; BSO: bilateral salpingo-oophorectomy; CCY: cholecystectomy; GIST: gastrointestinal stromal tumor; LSO: left salpingo-oophorectomy; OMT: omentectomy; RSO: right salpingo-oophorectomy; TAH: total abdominal hysterectomy. * Some procedures were performed at different time points.