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Concentration–response relationship curves (CRRCs) for mitoxantrone (MTO) and amantadine administered alone and in the combination at a fixed-ratio of 1:1, illustrating the anti-proliferative effects of the drugs in the human malignant melanoma cell lines (A375 (A), SK-MEL28 (B), FM55P (C) and FM55M2 (D)) measured in vitro by the MTT assay.
