Table 3.
Type I isobolographic analysis of interactions for parallel concentration–response relationship lines between amantadine and CDDP at the fixed drug concentration ratio of 1:1 in two melanoma cell lines FM55P and FM55M2. Results are median inhibitory concentrations (IC50 values in μg/mL ± S.E.M.) for two-drug mixtures, determined either experimentally (IC50exp) or theoretically calculated (IC50add) from the equations of additivity, blocking proliferation in 50% of tested cells in two melanoma cell lines (FM55M2 and FM55P) measured in vitro by the MTT assay.
| Cell Line | IC50exp (μg/mL) | nexp | IC50add (μg/mL) | nadd | Interaction |
|---|---|---|---|---|---|
| FM55M2 | 41.67 ± 6.68 | 96 | 34.95 ± 9.06 | 164 | Additivity |
| FM55P | 23.61 ± 6.22 | 96 | 20.36 ± 6.19 | 164 | Additivity |