Table 3.
Using a regimen of calcifediol * to rapidly raise serum 25(OH)D concentration above 50 ng/mL (125 nmol/L) in medical emergencies (i.e., to raise serum levels within four hours). ** A single body weight based, oral dose is calculated: 0.014 mg/kg body weight.
| Weight (lbs) | Weight (kg) | Calcifediol ~ (mg) # | If Calcifediol Is Not Available: Bolus/Loading Dose of Vitamin D3 ## |
|---|---|---|---|
| 8–14 | 4–6 | 0.05 | 20,000 |
| 15–21 | 7–10 | 0.1 | 40,000 |
| 22–30 | 10–14 | 0.15 | 60,000 |
| 31–40 | 15–18 | 0.2 | 80,000 |
| 41–50 | 19–23 | 0.3 | 100,000 |
| 51–60 | 24–27 | 0.4 | 150,000 |
| 61–70 | 28–32 | 0.5 | 200,000 |
| 71–85 | 33–39 | 0.6 | 240,000 |
| 86–100 | 40–45 | 0.7 | 280,000 |
| 101–150 | 46–68 | 0.8 | 320,000 |
| 151–200 | 69–90 | 1.0 | 400,000 |
| 201–300 | 91–136 | 1.5 | 600,000 |
| >300 | >137 | 2.0 | 800,000 |
* Calcifediol [partially activated vitamin D3, 25(OH)D]. ** Use the earliest possible in person with COVID-19, sepsis, Kawasaki disease, multisystem inflammatory syndrome, acute respiratory distress syndrome, burns, and vitamin D deficiency in early pregnancy and other clinical emergencies. # Measurement (or the concentration) of serum 25(OH)D is unnecessary. ## If calcifediol is unavailable, the equivalent dose of vitamin D is administered, as illustrated in Table 2, preferably in divided doses over three to five days. Irrespective of the regimen used, daily or weekly follow-up maintenance vitamin D dose is necessary as described in the text.