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. 2022 Jul 20;14(14):3516. doi: 10.3390/cancers14143516

Figure 1.

Figure 1

Antagonisms between HuR and microRNA-dependent regulation. HuR can interfere with miRNA-dependent regulation by different mechanisms: (i) HuR and miRNAs can compete for the binding to mRNAs due to overlapping binding sites; (ii) HuR, in concert with lncRNAs, can indirectly compete with miRNAs; (iii) HuR can directly sequester or inhibit miRNA expression; (iv) HuR can inhibit miRNA maturation (i.e., miR-199a); (v) HuR can promote lncRNA-dependent miRNA sponging. ONCO: Oncogenes; TS: Tumor Suppressor.