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(A) Time (100 µg/mL, 0–90 min) dependence and (B) concentration (30 min, 0–400 µg/mL) dependence images of cell uptake; (C) detection of mitochondrial targeting of CMMFTP with Mito-Tracker Green; (D) detection of the intracellular GSH depletion capacity of CMMFTP; (E) dark toxicity of CMMFTP in Hela cells; (F) dark toxicity of CMMFTP in normal cells; (G–I) comparison of the cytotoxicity of Cu-MOFs, Cu-MOF@MnO2, CMMFTP under different conditions. p < 0.05.
