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. 2022 Jul 18;14(14):3482. doi: 10.3390/cancers14143482

Figure 3.

Figure 3

DDR2 and POSTN promote tumor metastasis in cell-based assays. (A) Western blot showing increase in pSrc and pAKT in POSTN overexpression in DDR2-depleted CAFs. (B) Western blot showing POSTN overexpression in DDR2-depleted CAF106. (C) Mesothelial and CAF clearance by tumor cells using DDR2 knockdown and POSTN overexpression CAFs. (D) Analysis of assay in (C). (E) Matrigel transwell tumor invasion assay with ES2 cells using conditioned media from DDR2 knockdown and POSTN overexpression CAFs. (F) 3D Collagen tumor cell migration assay using conditioned media from DDR2 knockdown and POSTN overexpression CAFs. (G) Analysis of assay in (E,H) Analysis of assay in (F). ** p < 0.01, *** p < 0.001, **** p < 0.0001.