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. 2022 Jul 18;14(14):3482. doi: 10.3390/cancers14143482

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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DDR2 and POSTN promote tumor migration and spreading. (A) Increased tumor spheroid spreading with POSTN overexpression in DDR2-depleted CAF68hT in collagen 1 gel. (B) Analysis of assay in (A). (C) Increased tumor spheroid spreading with POSTN overexpression in DDR2-depleted CAF106 in Matrigel. (D) Analysis of assay in (C). (E) Increased tumor migration and wound healing with POSTN overexpression in DDR2-depleted CAF68hT. (F) Analysis of assay in (E). (G) Increased tumor migration and wound healing with POSTN overexpression in DDR2-depleted CAF106, and (H) Analysis of assay in (G). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.