Table 1.
Patient and treatment-related characteristics.
| Variable | Total n = 292 (100.0%) |
Group 1: No H&N RT n = 198 (67.8%) |
Group 2: H&N RT n = 94 (32.2%) |
p |
|---|---|---|---|---|
| Gender | ||||
| Male | 155 (53.1) | 96 (48.5) | 59 (62.8) | 0.024 * |
| Female | 137 (46.9) | 102 (51.5) | 35 (37.2) | |
| Diagnosis | ||||
| Hematological malignancy | 216 (74.0) | 147 (74.2) | 69 (73.4) | <0.001 * |
| Brain tumor | 19 (6.5) | 1 (0.5) | 18 (19.1) | |
| Solid tumor | 57 (19.5) | 50 (25.3) | 7 (7.4) | |
| Age at enrollment (y) | 32.15 (16.77–59.47) | 29.93 (16.77–59.47) | 39.34 (18.44–57.61) | <0.001 ** |
| Age at cancer diagnosis (y) | 5.20 (0.01–17.00) | 3.97 (0.01–17.00) | 7.47 (0.38–16.87) | <0.001 ** |
| 0 < 5 | 140 (47.9) | 114 (57.6) | 26 (27.7) | |
| 5 < 10 | 89 (30.5) | 47 (23.7) | 42 (44.7) | |
| 10 < 15 | 50 (17.1) | 27 (13.6) | 23 (24.5) | |
| >15 | 13 (4.5) | 10 (5.1) | 3 (3.2) | |
| Time since diagnosis (y) | 25.26 (15.94–49.04) | 23.96 (15.94–49.04) | 32.61 (16.50–45.57) | <0.001 ** |
| 0 < 10 | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| 10 < 20 | 64 (21.9) | 51 (25.8) | 13 (13.8) | |
| 20 < 30 | 132 (45.2) | 106 (53.5) | 26 (27.7) | |
| >30 | 96 (32.9) | 41 (20.7) | 55 (58.5) | |
| Chemotherapy | 281 (96.2) | 198 (100.0) | 83 (88.3) | <0.001 * |
| Alkylating agents | 200 (68.5) | 135 (68.2) | 65 (69.1) | 0.894 * |
| Vinca alkaloids | 241 (82.5) | 170 (85.9) | 71 (75.5) | 0.033 * |
| Epipodophyllotoxins | 84 (28.8) | 50 (25.3) | 34 (36.2) | 0.072 * |
| Anthracyclines | 185 (63.4) | 134 (67.7) | 51 (54.3) | 0.028 * |
| Platinum compounds | 31 (10.6) | 21 (10.6) | 10 (10.6) | 1.000 * |
| Antimetabolites | 202 (69.2) | 134 (67.7) | 68 (72.3) | 0.498 * |
| Radiotherapy | 114 (39.0) | 20 (10.1) a | 94 (100.0) | |
| H&N RT, to salivary glands | 81 (86.2) | |||
| H&N RT, not to salivary glands b | 6 (6.4) | |||
| H&N RT to salivary glands unclear c | 7 (7.4) | |||
| RT yes/no unclear d | 1 (0.5) | |||
| Stem Cell Transplantation | ||||
| Autologous | 11 (3.8) | 4 (2.0) | 7 (7.4) | <0.001 * |
| Allogeneic | 38 (13.0) | 16 (8.1) | 22 (23.4) | |
| SCT unclear | 1 (0.3) | 1 (0.5) | 0 (0.0) | |
| cGVHD | 3 (1.0) | 1 (0.5) | 2 (2.1) | <0.001 * |
| Use of medication | ||||
| Unknown | 7 (2.4) | 6 (3.0) | 1 (1.1) | 0.004 * |
| ≤3 medicines | 249 (85.3) | 176 (88.9) | 73 (77.7) | |
| ≥4 medicines | 36 (12.3) | 16 (8.1) | 20 (21.3) |
H&N RT; head and neck radiotherapy. * Fisher’s exact test; ** Mann–Whitney U test. a No H&N RT. b Field of irradiation was the neck. c Field of irradiation was part of the brain. d It was unclear whether the participant received radiotherapy. Values are presented as n (column %) or median (range). Numbers do not always add up to 100% because of rounding.