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. 2022 Jun 24;9(7):199. doi: 10.3390/jcdd9070199

Table 3.

Cardiovascular Drugs during Pregnancy.

Hypertension
(Safe in Pregnancy)
Heart Failure
(Safe in Pregnancy)
Pulmonary Hypertension
(Safe in Pregnancy)
Arrhythmias
(Safe in Pregnancy)
Anticoagulants/
Antiplatelets
(Safe in Pregnancy)
Not safe or Limited Data in Pregnancy
B
Oral alpha-methyl dopa *
Hydrochlorothiazide *
B
Bumetanide
Torsemide
Metolazone
Dobutamine
B
Sildenafil *
Epoprostenol
B
Lidocaine *
Sotalol
B
Enoxaparin *
Argatroban
Bivalirudin
Fondaparinux
Clopidogrel
Prasugrel
Not safe D
DOACs
Atenolol
Amiodarone
(Can be used as a last resort)
ACE-Inhibitors *
Aldosterone antagonists
Angiotensin receptor blockers
Statins
Dronaderone
Dofetilide
Ivabradine
C
Labetalol *
Clonidine
Nifedipine *
Amlodipine *
Nitroglycerin
Hydralazine *
Isodorbide dinitrate
Nitroprusside *
Bisoprolol *
C
Furosemide *
Carvedilol
Metoprolol *
Isosorbide dinitrate
Nitroglycerin
Norepinephrine
Hydralazine *
Dopamine
C
Iloprost
Treprostinil
C
Flecainide * (F)
Digoxin * (F)
Metoprolol *
Propranolol *
Labetalol *
Sotalol (F)
Adenosine *
Verapamil
Procainamide
Quinidine *
Atropine
C
Unfractionated heparin *
Aspirin (81 mg) *
Ticagrelor
D
Warfarin *
(Safe after first trimester until 36 weeks gestation)
Limited Data
Mexiletine
Ibutilide
Propafenone *
Disopyramide
Nadolol
Diltiazem

Former Food & Drug Administration ABCD categories along with the indications are listed. * Safe in lactation. (F) = Can be used for Fetal Tachycardia.