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Hepatitis B vaccines.
| Generation | Year | Type of Vaccine |
|---|---|---|
| I | 1982 | Plasma-derived vaccines |
| II | 1986 | Recombinant HBV DNA vaccine, expressed in yeast |
| III | 1990 | Recombinant pre-S/S vaccines expressed in mammalian cells |
| IV | Recombinant HBV vaccines with adjuvant (AS04, CpG) |
