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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Chem Phys Lipids. 2022 Apr 26;245:105205. doi: 10.1016/j.chemphyslip.2022.105205

Fig. 2.

Fig. 2.

SANS reveals the effects of membrane additives on domain stability. SANS data at 15 °C (a), 25 °C (b), and 35 °C (c) for the lipid mixture DPPC/DOPC/Chol 37.5/37.5/25 in the absence of ceramide (-cer, blue curve), or with 10 mol% of DPPC replaced by either C18:0-cer (orange curve), or C18:1-cer (red curve). C18:0-cer stabilizes domains as indicated by an increase in SANS intensity relative to the baseline, while C18:1-cer destabilizes them. Close to physiological temperature (c), C18:0-cer induces domain formation in the uniform baseline lipid mixture.