Achyrocline satureioides
|
Achyrobichalcone, 3-O-methylquercetin, and other flavonoids |
In vitro cytotoxicity and apoptosis in human breast cancer cells; inhibition of c-MYC and ERK/JNK in glioma cell lines. |
[82,131] |
Aloysia polystachya
|
Flavonoids |
In vitro apoptosis in human colorectal cancer cells, and a decrease in the percentage of cancer stem cells (CSCs). In vivo inhibition of tumor growth in non-toxic doses. |
[132] |
Azorella glabra
|
Mulinic acid, azorellane terpenoids |
G0/G1 cell cycle arrest and apoptosis in AML cell lines. A slight decrease in the survival of non-tumor cells |
[133] |
Ephedra chilensis
|
Terpens and fatty acids |
IC50 of non-polar extracts for one breast cancer and three colon cell lines was at the level of doxorubicin; in vitro cytotoxicity for normal colon epithelium cells was less than doxorubicin. |
[134] |
Croton lechleri
|
Taspine |
Leaf extracts exhibited cytotoxic antiproliferative effects on HeLa and SK23 cells in vitro, and antitumor effects in mice in vivo; moderate toxicity to mice. |
[135,136] |
Laetia corymbulosa
|
Corymbulosins B, C, D, E, F, G |
Bark extract exhibited cytotoxicity to panel of cancer cells. |
[137] |
Lepidium meyenii
|
macamide and macaene fractions |
Macadamine displayed anticancer activities against multiple cancer cell lines. |
[138] |
Leptocarpha rivularis
|
Leptocarpin |
Cytotoxic effects against several cancer cell lines. |
[139] |
Passiflora alata
|
Flavonoids and saponins |
In vitro cytotoxicity against the set of cancer cell lines, and in vivo antitumor activity against sarcoma S180-bearing mice with low general toxicity. |
[140] |
Thevetia peruviana
|
Thevetiaflavone, and individual cardiac glycosides |
Fruit extract exhibited cytostatic and cytotoxic effects in cancer cell lines with moderate toxicity to non-tumor cells. |
[141] |