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. 2022 Jun 29;12(7):860. doi: 10.3390/brainsci12070860

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Intra-LC infusions of enkephalin promote conditioned place preference. The experimental timeline is shown in (A). Rats were habituated to handling by the experimenter for 3 days but were naïve to the behavioral apparatus when conditioning began. Rats that received enkephalin infusions showed a strong trend for entering the conditioned side of the CPP apparatus with shorter latency than the rats that received saline infusions in the conditioned side (p = 0.0519, (B)). Rats that received enkephalin infusions in the conditioned side of the CPP apparatus showed a significantly greater preference for that chamber than rats that received saline infusions in the conditioned side (C). * p < 0.05.