Table 1.

Characteristics of YTHDF1 in Gastrointestinal Cancers.

Cancer	Expression	Function	Molecular Targets	Reference
Esophageal Cancer	Increased	Oncogenic	NA	[68,84,85]
Gastric Cancer	Increased	Oncogenic	PD-1, PD-L1, CTLA-4	[13,18]
			FZD7/β-catenin	[11]
			SPHK2	[16]
			JAK/STAT1	[17]
Colorectal Cancer	Increased	Oncogenic	FZD9/WNT6/β-catenin	[24]
			c-MYC	[27]
			ARHGEF2	[29]
			TCF4/DVL3/FZD7/β-catenin	[31,32]
			TEAD1	[33]
			TRAF6, DDX60, NLRP3	[36,37,38]
Hepatocellular Carcinoma	Increased	Oncogenic	SNAI1	[10]
			PI3K/AKT/mTOR	[55]
			EGFR	[57]
			AKT/GSK-3β/β-catenin	[56]
			FZD5/β-catenin	[54]
			PD-L1, mTOR, WNT	[47]
			HIF-1α, ATG2A, ATG14	[59]
			TGF-β, WNT	[61]
Pancreatic Cancer	Decreased	Tumor Suppressive	NA	[63,64,65,66]