Table 1.
The Top 20 significantly enriched MSigDB pathways associated with the specific lists of genes up-regulated in GASC-LS. The table reports the overall number (#) of genes involved in the annotated pathways, the number (#) of genes provided as input, and the associated p-value.
| GASC-LS UP | |||
|---|---|---|---|
| Gene Set Name | #Genes in Gene Set | #Genes in the Overlap | p-Value |
| REGULATION OF ION TRANSPORT | 1314 | 27 | 4.36 × 10−10 |
| NEUROGENESIS | 1613 | 30 | 4.52 × 10−10 |
| NOTCH_SIGNALING_PATHWAY | 186 | 11 | 2.59 × 10−9 |
| REGULATION_OF_TRANSPORT | 1730 | 29 | 9.28 × 10−9 |
| REGULATION_OF_CELL_DIFFERENTIATION | 1618 | 28 | 8.74 × 10−9 |
| NEURON_DIFFERENTIATION | 1357 | 25 | 1.77 × 10−8 |
| BMI1_DN_MEL18_DN.V1_DN | 147 | 9 | 5.55 × 10−8 |
| SECRETION | 1464 | 25 | 7.61 × 10−8 |
| MORF_DCC | 112 | 8 | 9.39 × 10−8 |
| BEHAVIOR | 541 | 15 | 9.61 × 10−8 |
| POSITIVE_REGULATION_OF_ION_TRANSPORT | 659 | 16 | 2.14 × 10−7 |
| MORF_EPHA7 | 139 | 8 | 4.96 × 10−7 |
| POSITIVE_REGULATION_OF_TRANSPORT | 882 | 18 | 4.66 × 10−7 |
| POSITIVE_REGULATION_OF_MULTICELLULAR_ ORGANISMAL_PROCESS |
1397 | 23 | 4.96 × 10−7 |
| POSITIVE_REGULATION_OF_DEVELOPMENTAL_ PROCESS |
1284 | 22 | 4.62 × 10−7 |
| CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT | 980 | 19 | 4.77 × 10−7 |
| MODULE_137 | 545 | 14 | 6.47 × 10−7 |
| MODULE_100 | 543 | 14 | 6.19 × 10−7 |
| MODULE_66 | 551 | 14 | 7.36 × 10−7 |
| HALLMARK_ANGIOGENESIS | 36 | 5 | 9.28 × 10−7 |