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. 2022 Jul 21;27(14):4648. doi: 10.3390/molecules27144648

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Different concentrations of MEL-B treatment increased the mRNA-level expression of genes associated with the skin barrier in UVB-irradiated HaCaT cells. mRNA levels reflecting the expression of genes encoding LOR (A), FLG (B), and TGM1 (C) were quantified using RT-PCR after the normalization of results to GAPDH mRNA expression levels (loading control). Increased mRNA expression of LOR, FLG, and TGM1 genes in UVB-induced HaCaT cells after MEL-B treatment (20 μg/mL, p < 0.01). Values are expressed as means ± SD (n = 3). # p < 0.05, ## p < 0.01, ### p < 0.001 vs. the control group (Ctrl); ** p < 0.01, *** p < 0.001 vs. the UVB-irradiated group (Mol).