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. 2022 Jul 15;14(7):1551. doi: 10.3390/v14071551

Figure 5.

Figure 5

The number of inferred amino acid changes (AA) associated with the sHCoVs for AA positions in the envelope, membrane, nucleocapsid, and spike proteins from datasets D4 and D5. Panel (A) represents the aggregated AA changes from the alphaCoVs 229E and NL63 while (B) represents the aggregated changes from the betaCoVs OC43 and HKU1. At the top of each plot, the functional domains or regions of the respective proteins are shown; NTD = N-terminal domain, TM = transmembrane domain, CTD = C-terminal domain, RBD = receptor binding domain, LINK = central linker domain, LINK-Dimer = dimerization domain, S1 subunit, S2 subunit, FP = fusion peptide, IFP = internal fusion peptide, HR1 = heptad repeat 1, and HR2 = heptad repeat.