Table 4 –
Outcomes and clinical practices.
| Overall n = 203 |
ARDS n = 146 |
No ARDS n = 57 |
P-value | |
|---|---|---|---|---|
| Alive and vent free days at 28 days, median (IQR) | 2 (0–23) | 1 (0–21) | 18 (0–25) | 0.03 |
| Alive and vent free days at 28 days, 28-day survivorsa, median (IQR) | 23 (17–26) | 22 (15–25) | 25 (23–27) | <0.01 |
| Hospital length-of-stay, median (IQR) | 13 (7–25) | 15 (7–26) | 10 (7–22) | 0.25 |
| Hospital mortality, n (%) | 102 (50.3) | 77 (52.7) | 25 (43.9) | 0.26 |
| Hospital disposition, n (%) | 0.13 | |||
| Home | 23 (11.3) | 12 (8.2) | 11 (19.3) | |
| Rehabilitation center | 73 (36.0) | 53 (36.3) | 20 (35.1) | |
| Death or hospice | 106 (52.2) | 80 (54.8) | 26 (45.6) | |
| Other | 1 (0.5) | 1 (0.7) | 0 (0) | |
| Use of midazolam, n (%) | 53 (26.1) | 43 (29.5) | 10 (17.5) | 0.08 |
| Not LTTV, Vt > 8 cc/kg, n (%) | 32 (15.8) | 22 (15.1) | 10 (17.5) | 0.66 |
| Driving pressure > 15 cmH2O, n (%)b | 50 (25.3) | 34 (23.9) | 16 (28.6) | 0.50 |
| Hyperoxia, PaO2 > 300 mmHg, n (%)c | 57 (28.5) | 37 (25.7) | 20 (35.7) | 0.16 |
| Fluid balance over 3 days in cc, median (IQR) | 3622 (170–7500) | 3450 (112–7600) | 3800 (600–6700) | 0.67 |
Abbreviations: LTTV (low tidal volume ventilation), Vt (tidal volume).
a
This included 99 patients who survived to 28 days.
b
Excludes 5 unknown driving pressures.
c
Excludes 3 unknown hyperoxia levels.